Rare earth based nanostructured materials: Synthesis, functionalization, properties and bioimaging and biosensing applications

Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.European Union 267226Ministerio de Economía y Competitividad MAT2014-54852-

Evaluación del área trabecular por digitalización de imágenes en el callo de fractura: estudio experimental

Se presenta un método de evaluación del área trabecular por medio de digitalización de imágenes de microscopía óptica. Se estudia la evolución de 20 callos de fractura en ratas de cepa Wistar, obteniendo un incremento progresivo del área trabecular desde los 14 a los 49 días, correlacionando ésta directamente con la actividad neoformativa. Se concluye proponiendo el uso de este método por su uniformidad, objetividad y reproductibilidad en todo el estudio, permitiendo la independencia del anatomopatológico.We present a method for assessment of the bone trabecular area by using optic microscope digitalized imaging. We studied 20 fracture callus performed at the tibia in Wistar rats. The bone trabecular area had a progressive increased from 14 to 49 days, post-fracture, been directly related with the neoformative activity. We propose this method because of this uniformity, objetivity and reliability. This method akows fracture repair analysis independently of the subjetivity of the pathologist

NECROSIS DE MIEMBROS INFERIORES POR CONGELAMIENTO

La necrosis de las extremidades se produce por disminución del aporte de oxígeno a las mismas ya sea de manera aguda o crónica, existen varias causas que pueden llevar a este tipo de patología, una de las cuales es el congelamiento, dichas lesiones inducidas por el frio que se observan cuando la temperatura ambiental se encuentra por debajo del punto de fusión y la efectividad de su tratamiento ya sea médico o quirúrgico dependerá del tiempo de evolución

PEC innovation

Due to the cognitive decline associated with aging, it is necessary to determine the variables involved in this process to implement preventive actions to avoid or help slow the progression of cognitive decline to dementia in older adults. This is a priority in the current pandemic situation, due to the consequences of periods of confinement due to COVID-19. To address these challenges, this study was conducted through Information and Communication Technologies (ICTs), by adapting an in-person assessment protocol into an online Tele neuropsychological consultation. The correlation between autonomy and cognitive performance variables is analyzed in 47 Mexican subjects over 60 years of age. The results of the statistical analyses suggest a moderate correlation between the level of autonomy and cognitive performance (with MOCA and Clock Drawing Test), significant correlation values are outlined in some of the variables reviewed, and interesting data were found in the correlation of cognitive reserve with cognitive decline and the educational level from the participants. Finally, future analysis is proposed of the sensitivity of screening tests (CDT) to find indicators of Mild Cognitive Impairment (MCI) in this population that is not detected in classical tests (MOCA). Developing ICT-based screening protocols for the elderly may be a key tool in these coronavirus times or under any given circumstances.PECInnovationhttps://www.sciencedirect.com/journal/pec-innovation/vol/2/suppl/

Libro de Actas de la "I Jornada para Alumnos de Trabajo Fin de Grado y Trabajo Fin de Máster: Uso Efectivo de Herramientas TIC"

Innovación EducativaEste libro de resúmenes engloba los trabajos presentados en la “I Jornada para alumnos de Trabajo Fin de Grado (TFG) y Trabajo Fin de Máster (TFM). Uso efectivo de herramientas TIC”, celebrada en Valladolid el 21 de marzo de 2019. Los trabajos aceptados tienen como autores a alumnos de TFG o TFM que han presentado su tema de estudio de TFG/TFM y los principales resultados obtenidos hasta el momento de acuerdo con los requisitos formales de la Jornada. Estos resúmenes cubren un amplio rango de temáticas, incluyendo el procesado de señales e imágenes o el diseño de dispositivos y redes de comunicaciones, entre otros. Todos los trabajos han seguido un proceso de revisión riguroso, siendo evaluados en profundidad por los miembros del Comité Organizador. Los editores del libro de resúmenes de la “I Jornada para alumnos de Trabajo Fin de Grado (TFG) y Trabajo Fin de Máster (TFM). Uso efectivo de herramientas TIC” agradecen enormemente a todos los alumnos, profesores y ponentes su participación en la Jornada, ya que su contribución ha sido imprescindible para la celebración de este evento.Vicerrectorado de Docencia de la Universidad de Valladolid (PID Nº 55: “Nuevas propuestas en la tutorización de Trabajos Fin de Grado y Trabajos Fin de Máster con el apoyo de entornos virtuales de aprendizaje colaborativo"

Un breve análisis de la mortalidad del Covid-19 en países de América Latina

In early the 2020, the world faced a pandemic caused by Covid-19, which created crises in the health systems and economy of all nations. In Latin America, 1,246,190 cases and 65,228 deaths were recorded during the first four months of that year. Therefore, this study analyzed the data from report 101 of the World Health Organization, with the intention of identifying the countries in Latin America most affected by this crisis. With the use of the Pareto diagram tool, it could be shown that, the sum of positive cases in the countries of Brazil, Peru, Ecuador and Mexico represent approximately 80% of the total report of contagions in Latin America, the number of most alarming cases was recorded in Brazil with more than 70000 and the number of contagions does not exceed 0.1% of the total population of each government, with the exception of Ecuador, which surpassed it. However, this virus was not fatal in the first quarter of 2020 in Latin American countries  A principios del año 2020, el mundo enfrentó una pandemia ocasionada por el Covid-19, lo cual generó crisis en la salud y en la economía de todas las naciones. En América Latina, se registraron 1 246 190 casos y 65 228 muertes durante los cuatro primeros meses de ese año. Por lo tanto, en este estudio se analizaron los datos del informe 101 de la organización mundial de la salud, con la intensión de identificar los países de América Latina más afectados por esta crisis. Con la utilización de la herramienta diagrama de Pareto, se pudo evidenciar que, la sumatoria de casos positivos en los países de Brasil, Perú, Ecuador y México representan aproximada el 80% del reporte total de contagiados en América latina, el número de casos más alarmante se registró en Brasil con más de 70000 y el número de contagios no supera el 0,1% de la población total de cada gobierno, a excepción de Ecuador el cual lo superó. No obstante, este virus no fue mortal en el primer cuatrimestre del 2020 en los países de Latino América

Nanocolumnar films: sustainable manufacturing and applications in biomedicine

Resumen del trabajo presentado en la 3rd International Conference on Nanomaterials Applied to Life Sciences (NALS 2022), celebrada en Santander (España), del 27 al 29 de abril de 2022Nanocolumnar films (NCFs) can be manufactured by glancing angle deposition with magnetron sputtering. This technique is environmentally friendly: it is carried out at RT in a single step (moderate energy consumption) and does not involve chemical products (no recycling issues). Depending on several parameters (namely the gas pressure, the electromagnetic power, the angle of inclination of the substrate and its possible rotation), the nanocolumnar structure can be controlled [1]. Moreover, this method can be scaled up to large surfaces, representing a valid approach for the industrial production of nanostructured films [2]. In particular, concerning biomedicine, NCFs made of Ti, Au and Pt have been fabricated and successfully employed in several applications. Ti NCFs can be used as antibacterial coatings for orthopedic implants [2,3]. Pt NCFs show improved properties as bioelectrodes for electric stimulation [4]. Finally, Au NCFs are excellent substrates for the identification of biomolecules in surface enhanced Raman spectroscopy, SERS [5]

Prevalence and distribution of intestinal parasites in stray dogs in the northwest area of Mexico

Zoonotic parasitic infections are a major global public and veterinary health problem and widespread among stray dogs. The objective of this study was to establish the prevalence of intestinal parasites in stray dogs in the urban, rural and coastal areas of Mexicali County in northwest Mexico. In 2014, from January to December, 380 stray dogs were captured. The entire small intestine, cecum and faeces samples were collected and examined by using simple zinc sulfate flotation and Lugol’s solution staining. Data were statistically analysed. Overall, about 21.5% of examined dogs were found positive for intestinal parasites. Toxocara canis was the most frequent detected parasite, with a prevalence of 7.1%, followed by Toxascaris leonina (5.5%), Cystoisospora spp. (5.0%), Taenia spp. (3.9%) and Dipylidium caninum (2.8%). Dogs were more frequently found to be infected with a single genus of intestinal parasite (18.7%) than co-infected (2.8%). Intestinal parasites were more prevalent in samples from the coastal area (25%) than in those from the rural (24.4%) and urban (20.6%) areas, however, only statistical association was found between capture area and specific intestinal parasitic infection. There were significant differences in the prevalence of taeniasis among two age groups (P<0.01). A seasonal peak of prevalence for intestinal parasitic infections was found during spring (P<0.05), corresponding with a seasonal peak of prevalence of T. canis (P<0.05). The wide range of isolated parasites indicated that people residing in this area are at risk of exposure to these potentially hazardous zoonotic pathogens

Contribution to van der Waerden's conjecture

AbstractIn this paper, we give two different elementary proofs for the inequality which states that the permanent of doubly stochastic matrices is greater than or equal to (n!/nn). This inequality was proved earlier by the author, and independently by Egorychev and Falikman

A Comprehensive Analysis of 21 Actionable Pharmacogenes in the Spanish Population: From Genetic Characterisation to Clinical Impact

The implementation of pharmacogenetics (PGx) is a main milestones of precision medicine nowadays in order to achieve safer and more effective therapies. Nevertheless, the implementation of PGx diagnostics is extremely slow and unequal worldwide, in part due to a lack of ethnic PGx information. We analysed genetic data from 3006 Spanish individuals obtained by different high-throughput (HT) techniques. Allele frequencies were determined in our population for the main 21 actionable PGx genes associated with therapeutical changes. We found that 98% of the Spanish population harbours at least one allele associated with a therapeutical change and, thus, there would be a need for a therapeutical change in a mean of 3.31 of the 64 associated drugs. We also identified 326 putative deleterious variants that were not previously related with PGx in 18 out of the 21 main PGx genes evaluated and a total of 7122 putative deleterious variants for the 1045 PGx genes described. Additionally, we performed a comparison of the main HT diagnostic techniques, revealing that after whole genome sequencing, genotyping with the PGx HT array is the most suitable solution for PGx diagnostics. Finally, all this information was integrated in the Collaborative Spanish Variant Server to be available to and updated by the scientific community.CEGEN is part of the initiative IMPaCT-GENóMICA (IMP/00009) co-funded by ISCIII and the European Regional Development Fund (ERDF). Additional funding was obtained from the ISCIII Project PI18/01242, within the Health Strategic Action, which is co-funded by the European Regional Development Fund (ERDF).Peer reviewe